What if there's one invisible process happening inside your body right now that's accelerating ALL of these problems?
In our previous articles, we talked about NAD+ and how it powers your cells.
Today, we're going deeper.
We're showing exactly how NAD+ decline creates a “cascade” of ageing that hits every major system in your body...
And why this might be the single most important thing to address for healthy longevity.
The Invisible Decline That's Ageing You
One system starts failing, which puts stress on another system, which breaks down a third system, and so on.
We call it a “cascade” of ageing,
And at the center of this cascade is something called NAD+.
What is NAD+?
We’ve already covered about NAD+ in this article, but here’s a quick recap.
NAD+ (nicotinamide adenine dinucleotide) is like an universal battery that powers your cells.
Every single process in your body - from making energy to repairing DNA - depends on NAD+.
When you're young, you have plenty of it.
But here's the problem:
NAD+ levels drop by 50% or more by the time you're 50. [1]
The NAD+ Cascade: How One Decline Triggers Everything Else
Your Cells Have Low Energy
It starts in your mitochondria - the tiny power plants inside every cell. (The same ones we read in Class 9 biology, and has become an internet meme)
These mitochondria use NAD+ to convert the food you eat into ATP (cellular energy).
When NAD+ drops, your mitochondria struggle to produce energy.
And when your cells are starving for energy, every function in your body slows down because there's not enough fuel to run.
Your DNA Repair System Breaks Down
Your DNA takes damage every single day. From stress, pollution, processed food, even just normal metabolism.
When things are normal, enzymes called PARPs fix this damage instantly.
But PARPs need NAD+ to function.
Low NAD+ means your DNA repair system breaks down.
You start recovering slower from workouts. Injuries take longer to heal. Your skin starts looking older faster. You catch every cold that goes around.
Your body can't keep up with daily damage. Cells start malfunctioning, tissues break down faster, and your biological age speeds up.
By the way, if you want to calculate your biological age, and see if you’re on the right track,
Check our free Bio Age calculator here
Your Brain Starts Losing Power
Your brain is the most energy-hungry organ in your body. It uses 20% of your total energy, even though it's only 2% of your body weight. [2]
When NAD+ drops and cellular energy production fails,
You start to get brain fog. You have trouble concentrating on complex tasks. You find yourself asking "where did I put my keys?" more often. You feel mentally slower than you used to.
Your Heart Struggles to Keep Up
Your heart never stops working.
About 100,000 beats per day. 35 million beats per year.
It needs massive amounts of cellular energy to keep pumping strong.
When NAD+ levels drop, your heart muscle can't generate the ATP it needs for powerful contractions.
You get tired easier during exercise. Your heart starts to beat harder during simple activities. Climbing stairs leaves you tired. Your overall stamina drops.
Your Muscles Start Burning Away
As NAD+ declines, your muscles can't maintain themselves properly.
You lose strength even if you exercise regularly.
Your muscles feel softer than they used to. You take longer to recover from workouts. You lose muscle mass despite eating enough protein.
Your Immune System Starts Breaking Down
Your immune cells are some of the most active cells in your body.
They're constantly patrolling, fighting off threats, and cleaning up cellular debris.
This requires enormous amounts of energy.
When NAD+ drops, immune cells can't function properly.
You catch every cold that goes around. You take longer to recover from illness. You develop chronic low-level inflammation. Your allergies get worse with age.
Your immune system becomes confused - both overactive which causes inflammation,
and underactive, which struggles to fight off real threats and makes you more prone to infections.
Why NAD+ Decline Accelerates After 40
NAD+ decline is a vicious cycle.
When your DNA repair systems break down, they can't fix the damage to your cells, tissues, and organs. This damage piles up in your heart, brain, muscles, and immune system.
Your body needs more NAD+ to repair this growing damage.
But you have less NAD+ available than before.
More damage builds up. You need even more NAD+ to fix it.
But your NAD+ levels keep dropping.
This is why ageing suddenly speeds up in your 40s and 50s.
You hit the point where NAD+ decline overwhelms your body's ability to keep up with daily damage.
But here's the good news:
This cascade can be slowed down.
The Most Effective Way To Slow Down NAD+ Decline
The most effective way to restore NAD+ levels is through targeted supplementation with NMN (Nicotinamide Mononucleotide) and Resveratrol
Required Reading → How To Improve Your Energy Levels With NMN and Resveratrol
And here’s the summary of that,
NMN restores your NAD+ levels.
Resveratrol activates repair systems that use NAD+.
Together, they stop the decline and start reversing it.
Within weeks of taking NMN + Resveratrol, your cellular energy becomes more sustainable, and that means,
You can think clearly and no longer struggle to focus.
You can climb stairs without getting tired.
You wake up feeling energetic instead of struggling to get up for 30 minutes to feel human.
You stop catching every cold your colleagues bring to the office.
But…there’s a catch, and a very important one.
NMN Supplementation Alone Isn't Enough
While NMN + Resveratrol can help you stop the decline we’re talking about,
supplementation alone won't give you maximum results.
Your body also needs the right foundation of exercise, nutrition, sleep and mental health to support NAD+ production and cellular repair
Required Reading → 5 Pillars Of Healthy Ageing
Make sure you read and apply what we speak about there. That’s important not only for our NMN supplement,
But also for all our supplements.
Your Next Step
The earlier you address NAD+ decline, the more you can slow ageing.
But even if you're already experiencing significant symptoms, restoring NAD+ levels can make a meaningful difference in how you feel and live.
Our goal here is to live a “quality” life where you’re independent and you get to enjoy as much as you can without worrying about ageing-related issues.
If you haven’t already, make sure you check out our NMN + Resveratrol supplement
References
[1] Zhu, X.H., et al. "Age-related NAD+ decline in human skin samples." PMC, 2020.
https://pmc.ncbi.nlm.nih.gov/articles/PMC7442590/
[2] Raichle, M.E. and Gusnard, D.A. "Appraising the brain's energy budget." PNAS, 2002.
