In our last article about NMN, we saw how the NAD+ and SIRT1 help your cells to repair themselves.
Now, we’ll go more about the science behind these.
Oh by the way…
If you’re considering taking our NMN+Resveratrol supplement, read this article to see “why” the supplement is important.
Let’s get into the details now.
Two compounds, NAD+ and SIRT1 do a lot of heavy lifting in repairing your cells as you age, keeping you healthy and getting you the benefits we spoke about in the previous article.
But most people have never heard of them.
That changes now.
What is NAD+?
NAD+ (nicotinamide adenine dinucleotide) is a “coenzyme”,
or…a “helper” molecule that fuels the most fundamental processes in your body.
Here’s what makes it essential:
Energy Production
NAD+ is a critical player in cellular metabolism.
It’s involved in the conversion of nutrients into ATP (the energy currency of your body).
It works inside your mitochondria during a process called cellular respiration,
(specifically two fancy science names called the Krebs cycle and electron transport chain)
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NAD+ grabs electrons (tiny packets of energy) from the broken-down nutrients.
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It then moves those electrons to the “electron transport chain”
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Those electrons spark a series of reactions that create ATP (adenosine triphosphate).
DNA Repair:
Your DNA takes a beating every day naturally…
Now add pollution, stress, processed foods, you name it, the damage is just accelerated.
Think of your DNA like a “library” filled with instruction manuals.
When DNA is damaged, the “pages” get torn and your body starts misreading the instructions.
And that’s when cells go haywire.. And things like cancers, mutations and ageing happen.
Here’s where NAD+ comes in to fix this.
It activates a group of enzymes called PARPs (Poly ADP-ribose polymerases).
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When DNA damage occurs, PARPs spot the break.
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PARPs sound the alarm and start a repair chain reaction, stitching the broken strands back together.
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The thing is, PARPs are powered by NAD+. Every repair they make drains NAD+ reserves like a battery.
No NAD+ = No DNA repair..
AD+ levels plummet with age. By the time you’re 40, your NAD+ can be half of what it was in your 20s. Lower NAD+ = slower energy production, weaker cellular repair, and the creeping signs of ageing.
Now, this is where SIRT1 enters the picture.
What is SIRT1?
SIRT1 is a member of the sirtuin family.
They are proteins that regulate cellular health. Not the kind of proteins you find in your food and supplements, but the kind that act as your body’s internal repair crew. Think of it like the body’s built-in repair and stress management system.
But it doesn't just work independently.
SIRT1 is activated by NAD+.
Without enough NAD+, SIRT1 can't do its job effectively.
And what is its job?
Cellular Repair: SIRT1 helps regulate gene expression and fix damaged cells, extending their lifespan and delaying cellular ageing.
Inflammation Control: Chronic inflammation is like a slow-burning fire in the body, linked to nearly every age-related disease. SIRT1 helps tamp it down.
Metabolic Balance: SIRT1 influences fat metabolism and insulin sensitivity, keeping energy levels stable and reducing metabolic dysfunction as you age.
The problem is no surprise here.
SIRT1 also declines with age, in part because it relies on dwindling NAD+ reserves.
The ageing Problem: Why NAD+ and SIRT1 Decline Over Time
If NAD+ and SIRT1 are so vital..so critical for keeping your cells energized and healthy..
Why do they fade as you get older?
Here’s the uncomfortable truth:
Your body naturally breaks down over time. Not because it’s failing, but because the systems that protect it slowly wear out.
When you’re young, your cells produce plenty of NAD+.
Your mitochondria are flooded with this molecule.
Every time you eat, NAD+ helps convert nutrients into ATP, pure cellular energy that powers:
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Your heartbeat.
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Your muscle contractions.
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Your brain activity.
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Even the microscopic reactions happening as you read this right now.
But here’s the catch
NAD+ is consumed every time your body produces energy and every time your cells repair damage.
And as you get older your body stops recycling it as efficiently.
There’s a biological system responsible for restoring NAD+ called the NAD salvage pathway.
And when it repairs more and more damage, it drains your NAD+ reserves.
And when the damage becomes too much? The repair slows.
Cells stay damaged longer. And your biological age accelerates.
Can You Boost NAD+ and SIRT1 Naturally?
The good news? Yes, you can absolutely support your body's NAD+ and SIRT1 activity.
Like we already saw in our previous article
Lifestyle changes and supplementation are essential. Especially regular exercise, since it produces NAD+ (but it may not be sufficient, and there is not enough clinical evidence that says exercise can help boost NAD+ levels)
And, the most effective way to restore declining NAD+ and SIRT1 levels is through targeted compounds like NMN + Resveratrol.
We’ll not go too detailed into it, as we’ve covered it already.
What Now?
You already know what NAD+ and SIRT1 do.
Now it’s about what you do next.
You can move around easier..Things like climbing stairs or running with your kids becomes effortless, and your mind feels sharp, clear and focused.
You feel better..and if you make the right lifestyle changes…you may even feel..
UNSTOPPABLE.
Your cells are asking for the right fuel to get you there.
NMN to restore NAD+ and Resveratrol to activate SIRT1.
